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Quinidine
  • Quinidine

Quinidine

Item No.: CAS: 56-54-2
Product Name: Quinidine
CAS: 56-54-2
MF: C20H24N2O2
MW: 324.42
EINECS: 200-279-0
Appearance: Crystals or white powder
INQUIRY
Quinidine is a commonly used class I antiarrhythmic drug. It is a stereoisomer of quinine, originally derived from the bark of the cinchona tree. It exerts its antiarrhythmic effects on the heart by interacting with the electrophysiology mechanisms that cause arrhythmias to modify the abnormalities in impulse initiation and conduction. Quinidine depresses normal automaticity in cardiac fibers that may act as ectopic pacemakers causing arrhythmias. Quinidine also blocks the slowly inactivating, tetrodotoxin-sensitive Na current, the slow inward calcium current (ICa), the rapid (IKr) and slow (IKs) components of the delayed potassium rectifier current, the inward potassium rectifier current (IKI), the ATP-sensitive potassium channel (IKATP) and Ito.
 

Uses:

This medication is used to treat or prevent many types of irregular heartbeats (heartarrhythmias such as atrial fibrillation). Quinidine can greatly improve your ability to perform normal activities by decreasing the number of irregular heartbeats you have. However, it may not stop all your irregular heartbeats completely. It works by blocking abnormal heartbeat signals.

Before and while you are using quinidine, your doctor may prescribe other medications (e.g., "blood thinners"/anticoagulants such as warfarin, beta blockers such as metoprolol) to shrink any bolld clots in the heart and to slow your pulse.


How to use Quinidine Gluconate:

Before starting this drug, the manufacturer recommends that you take a test dose (usually a smaller amount than your regular dose) to determine whether you are allergic to it. Consult your doctor or pharmacist for details.

Take this medication by mouth with or without food with a full glass of liquid (8 ounces/240 milliliters) as directed by your doctor. This medication is best taken on an empty stomach, but taking it with food may help decrease stomach upset. Do not lie down for 10 minutes after taking this medication.

Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

There are different brands and forms of this medication available. Not all have identical effects. Do not change quinidine products without talking to your doctor or pharmacist.

Dosage is based on your medical condition and response to treatment. If you are taking regular-release quinidine for an irregular heartbeat, the manufacturer recommends that you take no more than 4 grams daily.

Avoid eating grapefruit or drinking grapefruit juice while being treated with this medication unless your doctor instructs you otherwise. Grapefruit juice can change the amount of certain medications in your bloodstream. Consult your doctor or pharmacist for more details.

Avoid large changes in your dietary salt intake while being treated with this medication unless your doctor instructs you otherwise. The amount of salt in your diet may affect the amount of quinidine absorbed by your system. Consult your doctor or pharmacist for more details.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.

Tell your doctor if your condition does not improve or if it worsens.



 

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