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  • Prilocaine


Item No.: CAS: 721-50-6
Product Name: Prilocaine
CAS: 721-50-6
EINECS: 211-957-0
MF: C13H20N2O
MW: 220.31
Assay: 99%
Appearance: White powder
Grade:Pharmaceutical Grade
Prilocaine is a local anesthetic of the amino amide type first prepared by Claes Tegner and Nils. In its injectable form (trade name Citanest), it is often used in dentistry. It is also often combined with lidocaine as a topical preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia. As it has low cardiac toxicity, it is commonly used for intravenous regional anaesthesia.

Lidocaine and prilocaine topical cream is used on the skin or in the genital area to cause numbness or loss of feeling before certain medical procedures. It is used to prevent pain caused by an injection, the drawing of blood from a vein, or minor surgeries such as removing warts. This medicine contains a mixture of two topical local anesthetics (numbing medicines). It deadens the nerve endings in the skin.


Items Tested Specification Result
Characters White or almost white crystalline powder Confirms
Melting Point 166ºC-169ºC 166.5ºC-168.5ºC
Solubility Freely soluble in water and in alcohol Confirms
Assay (HPLC) 99.0--101.0% (calculated on the dried basis) 99.6%
Loss on Drying Not more than 0.3% 0.16%
Related substances Not more than 1.0% 0.11%
Acetone Not more than 5000ppm conforms
Ethanol Not more than 5000ppm conforms
Sulphated ash Not more than 0.15% conforms
Heavy Metal Not more than 0.001% <0.001%
Conclusion Conforms USP36

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