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Lidocaine
  • Lidocaine

Lidocaine

Item No.: CAS: 137-58-6
Product Name: Lidocaine
CAS Registry Number: 137-58-6
EINECS: 205-302-8
Molecular Formnula: C14H22N2O
Molecular Weight: 234.34
Appearance: White Crystalline Powder
Grade: Pharmaceutical Grade
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Description:

Lidocaine, xylocaine, or lignocaine is a common local anesthetic and class-1b antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning, and pain from skin inflammations, injected as a dental anesthetic, or as a local anesthetic for minor surgery.It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic healthcare system.

Lidocaine is the most important class-1b antiarrhythmic drug; it is used intravenously for the treatment of ventricular arrhythmias (for acute myocardial infarction, digoxin poisoning, cardioversion, or cardiac catheterization) if amiodarone is not available or contraindicated. Lidocaine should be given for this indication after defibrillation, CPR, and vasopressors have been initiated. A routine prophylactic administration is no longer recommended for acute cardiac infarction; the overall benefit of this measure is not convincing.

Application:

Lidocaine topical jelly or ointment is used on different parts of the body to cause numbness or loss of feeling for patients having certain medical procedures. It is also used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, minor cuts, or scratches.

Lidocaine viscous topical solution is also used to treat sore mouth or throat and also reduce gagging during the taking of X-ray pictures and dental impressions

Lidocaine skin patch is used to relieve pain caused by shingles (postherpetic neuralgia).

Lidocaine belongs to the family of medicines called local anesthetics. This medicine prevents pain by blocking the signals at the nerve endings in the skin. This medicine does not cause unconsciousness as general anesthetics do when used for surgery.

Dosage:

Xylocaine (lidocaine) MPF is a sterile, nonpyrogenic, isotonic solution containing sodium chloride. Xylocaine (lidocaine) in multiple dose vials: Each mL also contains 1 mg methylparaben as antiseptic preservative. The pH of these solutions is adjusted to approximately 6.5 (5.0-7.0) with sodium hydroxide and/or hydrochloric acid.

Xylocaine (lidocaine) MPF with Epinephrine is a sterile, nonpyrogenic, isotonic solution containing sodium chloride. Each mL contains lidocaine hydrochloride and epinephrine, with 0.5 mg sodium metabisulfite as an antioxidant and 0.2 mg citric acid as a stabilizer. Xylocaine (lidocaine) with Epinephrine in multiple dose vials: Each mL also contains 1 mg methylparaben as antiseptic preservative. The pH of these solutions is adjusted to approximately 4.5 (3.3-5.5) with sodium hydroxide and/or hydrochloric acid. Filled under nitrogen.


Lidocaine, along with ethanol, ammonia, and acetic acid, has also been proven to be effective in treating jellyfish stings, both numbing the affected area and preventing further nematocyst discharge.

Specification:

 
TEST ITEMS SPECIFICATION RESULTS
Characters A white or almost white crystalline powder A white crystalline powder
Identification Infrared absorption spectrum of the substance is same as that of Lidocaine Intermediate CRS Conforms
Clarity and color of the solution Clear and colorless≤Y6 Conforms
PH Dissolve 2.0g in water and dilute to 20ml ph 3.5~5.5 4.3
Optical rotation 4%(W/V)Water solution +135°~+150° +140°
Heavy metal ≤5ppm <5ppm
Sulphated ash ≤0.5% 0.02%
Water content 3.1~4.6% 4.1%
Acetone ≤0.5% 0.04%
Butyl alcohol ≤0.5% 0.004%
Bacterial endotoxins ≤0.5 CFU/g <0.5 CFU/g0.5 CFU/g
Assay 89.5%~102.0% 95.9%
B of Lidocaine≤5.0% 5.0
Conclusion The specification conform with enterprise standard

 

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