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NR, Nicotinamide Riboside CAS 1341-23-7

Health Benefits of Nicotinamide Riboside:

1) Nicotinamide Riboside Helps Muscle Function

NR administration rapidly restored muscle mass. Additionally, it preserved muscle NAD levels and exercise capacity, helping maintain muscle mass and function.
NR also stimulated mitochondrial unfolded protein response, which protects against mitochondrial disease.

2) Nicotinamide Riboside Helps Fight Against Cancer

NR can be used to generally limit tumor growth with high levels of oxidative stress.
Low levels of NAD+ synthesis can cause DNA damage. NR supplementation increases NAD+ levels, which can help protect against DNA damage, oxidative damage, and tumor progression

3) Nicotinamide Riboside Reduces Diabetic Symptoms

NR supplementation improved glucose tolerance, reduced weight gain, and reduced liver damage.

4) Nicotinamide Riboside Protects the Brain

Proper NAD metabolism can help protect the brain. NR protects the nerve cells in the brain by activating the SIRT3 and PGC1a pathways.
NR can also delay axonal degeneration, which can preserve nerve cells. Supplementation stimulates the NAD pathways and helps prevent degeneration in the brain.

5) Nicotinamide Riboside Protects the Liver

Oral administration of NR naturally increases NAD in the body, which helps protect the liver.

6) Nicotinamide Riboside Prevents Hearing Loss

It reduces degeneration of nerve cells caused by noise exposure.

7) Nicotinamide Riboside Increases Metabolism

8) Nicotinamide Riboside May Help with Weight Loss

NR may increase enzymes involved in burning fat (sirtuin enzymes), and energy expenditure thus helping with weight loss.

9) Nicotinamide Riboside Increases Longevity

NR increases the amount of NAD in the body, which can help reprogram dysfunctional cells. 

Food Sources of Nicotinamide Riboside:

1. Cow's milk  
2. Whey Protein 
3. Brewer's yeast


1. Nicotinamide riboside is a naturally occurring form of vitamin B3. There was no risk of death at an oral dose of 5000 mg/kg.

2. The lowest adverse effect level on organs for NR was 1000 mg/kg/day, and the no adverse effect level was 300 mg/kg/day.
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